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KMID : 1123920020160040823
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 4 p.823 ~ p.829
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Inhibitory Effects of Silsosangami on the Platelet Aggregation
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Kim Jong-Soo
Kim Beob-Jin
Kim Han-Geu
Ahan Jong-Chan
Lee Soo-Kyung
Chung Tae-Wook
Choi Dall-Yeong
Kim Cherl-Ho
Park Won-Hwan
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Abstract
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The thrombosis importantly came to the front as the risk factor of these circulation system’s disease. SilsoSanGami(SSG) was used for investigating the inhibitory effect on platelet-activating factor-induced platelet aggregation about drugs that used to improvement various symptoms created by the thrombosis in oriental medicine. In this study, the water-extracted SSG was investigated for its possible antithrombotic action on platelets. The antithrombotic activity of water-extracted SSG was deduced from its ability to suppress platelet aggregation, ATP-exocytosis, and the generation of prostaglandin E₂ and thromboxane A₂ by human platelets, stimulated with arachidonic acid. Water-extracted SSG dose-dependently suppressed the aggregation of human platelets, the release of endogenous ATP, and the formation of PGE₂ and TXB₂, both the latter usually detected to estimate the activity of COX and TXS, respectively. Since the IC/sub 50/ values necessary to inhibit COX (115 ㎍/㎖ SSG) and TXS(74 ㎍/㎖ SSG) were in the same range, inhibition of COX is suggested to be the primary target of water-extracted SSG, thus suppressing the formation of PGE₂ which is metabolized by TXS to TXA₂. We considerated that SSG has practical applicational value of clinical trial in the thrombosis caused by platelet aggregation.
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KEYWORD
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SiisoSanGami(失笑散加味), thrombosis, platelet aggregation, COX, TXS, PGE₂
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